Due to the regenerative properties of platelet-rich plasma and thrombin serum, current clinical practice shows different approaches in surgical application.
Studies have shown that adult mesenchymal stem cells, osteoblasts, fibroblasts, endothelial cells and epidermal cells express the cell membrane receptors for growth factors in PRP.
The local enrichment of these factors (higher concentration) to the defect significantly promotes the regeneration of the corresponding tissues. Since the platelets used remain active over a longer period of time, a single injection is sufficient to permanently initiate the healing of the tissue.
This retrospective study shows that routine use of PRP can significantly reduce the incidence of both DSWI and SSWI without adverse reactions. In addition, the cost of preventive treatment with PRP is definitely lower than a 1-day hospital stay.
For a more precise description, more clinical data is needed on possible indications such as:
The regenerative potential of PRP and ATS can be biologically optimised by adding bone marrow aspirate concentrate.
Depending on the field of application, a manufacturing licence is required for the use of BMC.
Application of BMC in Orthosurgery
"Biological and clinical interest in MSC has increased dramatically over the past two decades, as demonstrated by the ever-growing number of research teams studying these cells."