Studies have shown that adult mesenchymal stem cells, osteoblasts, fibroblasts, endothelial cells and epidermal cells, express the cell membrane receptors for growth factors in PRP.

Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg, 2004

Histological preparation of the split skin graft donor site after 6 days. There is no epithelial budding and the connective tissue shows macrophages, and young thick fibroblasts without significant collagen production (haematoxylin and eosin stain, original magnification: x10).

Histological preparation of the split skin graft donor site, treated with platelet-rich plasma, after 6 days. A pronounced epithelial budding is visible and the underlying connective tissue shows mature dermis development with collagen deposition (haematoxylin and eosin stain, original magnification: x10).


"Studies have shown that adult mesenchymal stem cells, osteoblasts, fibroblasts, endothelial cells and epidermal cells express the cell membrane receptors for growth factors imv PRP. These transmembrane receptors in turn induce activation of an endogenous internal signalling protein that causes (unlocks) expression of a normal cell gene sequence, such as cell proliferation, matrix formation, osteoid production, collagen synthesis, etc. The significance of this finding is that PRP growth factors never enter the cell or its nucleus, they are not mutagenic and they work by stimulating normal healing, just much faster. Therefore, PRP has no ability to induce tumour formation and never has."

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